Antibiotic Susceptibility of Helicobacter pylori From Gastric Biopsy of Patient Attending Benue State University Teaching Hospital, Makurdi, Benue State

Helicobacter pylori is a Gram-negative bacterium that causes chronic infections such as gastritis, peptic ulcer, gastric cancers and gastric malt lymphoma. The aim of the study was to assess the distribution of Helicobacter pylori from patients referred for endoscopy at Benue State University Teaching Hospital (BSUTH), Makurdi. Two (2) gastric biopsy samples (n=160) were obtained from the antrum of 80 consenting endoscopy patients at BSUTH, Makurdi, and used for isolation, identification of H. pylori using standard microbiological techniques. Antibiotic susceptibility determination was by the Clinical and Laboratory Standards Institute (CLSI) M100-Ed33 standard. Positive culture results were, however, poor as only one (1.25%) H. pylori isolate was isolated, which showed a 14 (82. 4%) susceptibility rate to Amoxicilin (20µg), Augmentin (20/10µg), Ampiclox (10/10µg), Zinacef (30µg), Gentamycin (10µg), Nitrofurantoin (300µg), Streptomycin (10µg), Tetracycline (30µg), Erythromycin (15µg), Clarithromycin (15µg), Chloramphenicol (30µg), Moxifloxacin (5µg), Ciprofloxacin (5µg), and Ofloxacin (5µg), and a 3 (17.6%) resistance to Ceftriaxone (30µg), Pefloxacin (5 µg) and Cotrimoxazole 1.3/23.8µg). The susceptibility of the isolated bacterium to most of the antibiotics used showed encouraging prospects for eradication therapies