One Pot Facile Synthesis and Characterization of 2-(Phenyl-2- sulfonylamino)-6-methylpyridine

This research reports a one-pot facile synthesis of 2-(phenyl-2-sulfonylamino)-6-methylpyridine. The sulfonamide was synthesized from the reaction of benzene sulfonyl chloride and 2-amino-6-methylpyridine in the presence of aqueous Na2CO3 serving as an HCl scavenger. The synthesized compound was obtained at a yield of 78 %. The synthesized product was structurally elucidated using data obtained fromFourier Transform Infrared Spectrometer (FTIR) and Nuclear Magnetic Resonance spectrometer (1H NMR and 13C NMR). FTIR spectrum showed bands at 3232.80, 1442.08, 1522.08, 1604.83,1273.06, 1705.13, 1365.65 and 2955.04 cm-1, 1H NMR spectrum peaks were observed at δ7.88, 7.85, 7.84, 7.62, 7.54, 7.51, 7.50 and 2.31ppm and 13C NMR spectrum peaks were seen at δ154.91, 151.92, 143.91,141.91, 132.24, 126.97,129.33, 113.97,and 111.56 ppm. All spectrometric spectral bands and peaks obtained corresponded to those of sulfonamides.